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Saturday, January 14, 2017

Could Cancer Drugs Treat Autism?

A surprising genetic connection has autism researchers wondering if they can borrow from cancer’s medicine cabinet.

"Five years ago, on Charlie Ryan’s second birthday, a big lump mysteriously formed on the side of his abdomen. At the emergency room his parents took him to, doctors suggested the lump was a hernia caused by some unknown trauma, and referred the family to a surgeon. The surgeon told them it was a benign tumor, and sent them home.

Charlie already had a host of medical issues. He’d been born with an abnormally large head and other features of autism, including being nonverbal. Now this.

Two years later, after visits to multiple doctors and the nine months it took for his genetic test to be analyzed, her hunch proved right. Charlie has a mutation in PTEN. Ryan immediately faxed the results to Charis Eng, a PTEN expert at the Cleveland Clinic in Ohio, whose name she had come across in her research. A few months later, the family made their first trip from their home in Tulsa, Oklahoma, to see Eng and her colleague, autism expert Thomas Frazier. Together, Eng and Frazier have treated more than two dozen children like Charlie—who all have PTEN mutations, autism, and large heads.

Read more here at The Atlantic.