Wednesday, January 21, 2015

Maternal thyroid autoantibody and elevated risk of offspring autism

Based on data collected from the Finnish Prenatal Study of Autism (FiPS-A), looking at possible pregnancy and birth factors associated with an offspring diagnosis of autism, researchers set about analysing archived serum samples from mums-to-be for positivity to thyroid peroxidase antibody (TPO-Ab), an immune reaction to an important enzyme involved in the production of thyroid hormones. The presence of TPO antibody is more usually associated with a diagnosis of Hashimoto’s thyroiditis, an autoimmune condition. Researchers found that in pregnancies that eventually gave rise to a child with autism, a positive result for TPO antibody was more likely to be present compared with controls with offspring who were not subsequently diagnosed with autism. Although not universally linked, the authors concluded that a positive TPO antibody result in maternal serum elevated the odds of offspring autism by approximately 80% compared to those negative for the antibody.

 Read more here.